Why Cannabis Affects People Differently
Two people try the exact same cannabis product and walk away with opposite stories. One says it was calming. The other says it was nothing like they expected. So whoโs right?
Read the transcript
Hello, humans, and welcome to the Planet 13 podcast. I am your host, Lady Lux, and today I want you to imagine something. I want you to imagine two people are having a conversation about the exact same cannabis product. One of those people says, that was a completely different experience than what I was going to expect. And the other one responds with, Really? That wasn't my experience at all.
It's the same product, has the same name, and it's potentially even the same batch, but we've had two completely different accounts of experiences. So who's right? Wow. They could both be accurately describing what they experienced, and that's what makes today top today's topic so interesting is why does cannabis affect everyone differently? So let's dive into it. First, we need to establish something important. Cannabis doesn't interact with every person in exactly the same way.
And that might sound obvious, but the cannabis industry often uses language that makes certain experiences sound almost like guaranteed. This product is relaxing, or this product is uplifting, or this strain is creative, or that strain is calming. And suddenly we're talking about human responses as though they they're a predicted light switch, right? Or as predicted was a light switch. You can flip it on and you can flip it off and you can get the expected results that are desired.
Except the human body doesn't work that way at all. And so I want to start with biology. Our bodies contain something called the endocannabinoid system. And it's a complex signaling system involved in several physiological processes. It includes cannabinoid receptors, naturally occurring signaling molecules, and enzymes that help regulate those molecules. THC interacts with this system, particularly though, particularly through cannabinoid receptors known as CB1 receptors. And these receptors are found throughout the central nervous system and in other tissues.
But knowing that THC interacts with a receptor doesn't mean we can predict every response because human biology is complicated and people differ in their physiology, their metabolism, and their sensitivity. And those differences can influence how they respond to substances, including cannabis. So here's a useful comparison. Think about caffeine. One person drinks coffee, they barely notice it. Others, like myself, they drink the same amount and they are noticeably stimulated, profusely sweating, and running around with all this energy that they need to expel.
Someone else might experience completely unwanted effects or undesirable effects, right? And we recognize that people respond differently to caffeine. Yet with cannabis, we sometimes expect a product subscription to predict exactly how everyone will feel when we don't do that with other things like caffeine or coffee. Like if I ordered a blonde roasted and the labeled it being labeled that way wasn't an expectation of how it was supposed to feel, and someone else drinks it and has a completely different experience, then that expectation doesn't account for all the individual variations.
Now I also want to talk about exposure. A person's history with cannabis can influence their response. And repeated exposure to THC can lead to tolerance to some effects. And that means the same amounts may not produce the same response over time. But tolerance isn't uniform. It can differ across individuals and across different effects. It also doesn't eliminate the possibility of impairment or other risk. And someone's previous experience is therefore relevant information, but it isn't a guarantee of what will happen next.
Another important factor is the product itself. Cannabis isn't a single chemical. Products can contain different amounts of THC, CBD, and other constituents. Two products with the same THC percentage may have different overall chemical profiles, and different product formulations can produce different patterns of exposure. Researchers are still investigating how individual cannabis compounds interact with combinations, interact, and with which combinations may influence particular outcomes. That's why broad promises about specific strains or terpene profiles deserve caution.
We don't have enough evidence to predict a precise personal response from a product name or an aroma alone. Now let's add in another variable: the circumstances. A person's surroundings, expectations, and current state can influence their subjective experience. This is sometimes discussed using the phrase set and setting. Set refers broadly to a person's mindset and internal circumstances. Setting refers to the surrounding environment. And these concepts are not unique to cannabis.
Context can influence how people perceive many experiences, but there is an important limitation. A comfortable environment doesn't guarantee a positive response or eliminate the risk associated with THC. It's only one factor among many. Now let's return to the two people. They encountered the same product, but they aren't the same person. They may have different biological characteristics, and that's expected. Different exposure histories, different expectations, different circumstances, and possibly different amounts of exposure.
So when their descriptions don't match, it doesn't automatically mean that one person is exaggerating, or it doesn't automatically mean the product is inconsistent. It means we need more information before drawing conclusions. So here's another question: Can someone have different experiences with the same product at different times? Yes. And why is that? It's because the human physiology and circumstances change. Previous exposures can change. The amount involved can change.
And even products sold under the same name can vary between batches. So a person's earlier experience isn't a perfect prediction of a future one. That uncertainty matters, especially when product descriptions are presented as promises. Now I want to address something the cannabis industry loves, which is reviews. Someone writes, five stars, this is the most relaxing product I've ever encountered. And then another person writes, one star completely different from one of what I expected.
Those reviews may both reflect genuine personal, personal experiences. And I emphasize personal because neither one establishes a universal outcome. A review tells us what happened to one person under circumstances we may not fully understand. It doesn't tell us what will happen to everyone else. It only gives us an indication of what that person experienced. And it doesn't replace accurate product information or safety testing. And this brings us to the bigger lesson.
We need to separate three different things. What a product contains, what someone reports experiencing, and what scientific research can reliably establish. Those are related, but they're not interchangeable. A lab report describes measured product characteristics. A personal review describes an individual's account of their experience. A scientific study investigates questioning using a defined method and population. And each of those provides a different kind of information. And each has limitations.
So why does cannabis affect everyone differently? Because the response is influenced by more than the name on the package. We understand that biology matters, exposure matters, product composition matters, the amount and the pattern matter, circumstances matter, and individual variation matters. That's a much more complicated explanation than saying this strain always does this. But it's also a more accurate one. I'll leave us with this today. The next time two people describe completely different experiences with the same cannabis product, instead of asking which person is right, I want us to ask what information might explain the difference.
Because understanding cannabis isn't just about understanding the plant, it it's also about understanding how much variation exists between the people and people encountering it. And until next time, stay curious, stay intentional, and keep asking better questions.
